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The rise of the infamous MacDefender malware in 2011 has set an example cyber criminals are likely to follow in the coming year.



From v3.co.uk:
First discovered in May, the MacDefender infection menaced users throughout the summer. Posing as a security tool, the infection used phony alert dialogues to convince users to pay a registration fee for the software.
When Apple took steps to isolate and block the infection, the malware was repackaged with workarounds to avoid detection.
  MacDefender shows the way for OS X malware in 2012